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Nafisa Joseph was born March 28, 1978 Bangalore, Karnataka, India to Nirmal Joseph, a Keralite Syrian Christian and Usha Joseph, a Bengali, who was a descendant of Tagore and first cousin of Sharmila Tagore. Nafisa studied at Bishop Cotton Girls' School and St. Joseph's College, both at Bangalore. She was Catholic, but owed her Islamic first name to the fact that her paternal grandmother was Muslim. Had an older sister.
Never married and had no children, she committed suicide by jumping on July 29, 2004 at the age of 26. On February 8, 2006, a year and 4 months after her death, her close friend Kuljeet Randhawa committed suicide by the same way at the age of 30.
