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Growing up on America's east coast, mainly based in New Jersey, Kelly-Anne found a passion for performing arts. She excelled in ballet, singing, and acting as a teenager, taking part in local musical theatre productions and becoming a member of the New Jersey Ballet Junior Company, with whom she performed in productions such as The Nutcracker.
While in New York City receiving her BA degree, Kelly-Anne enjoyed taking acting classes. An NYC based modeling agency also signed Lyons, which began her modeling career. Shortly before graduation, Lyons was scouted by a UK based modeling agency who encouraged her to move to London, which she did one week after receiving her university degree, magna cum laude. Among the brand campaigns she has modeled for are Special K, The Body Shop, Fila, Fitness First, Microsoft, and John Lewis.
However, acting has always been Lyons focal point and her credits on stage include Footloose, Father of the Bride, and Much Ado About Nothing.
Kelly-Anne first burst onto the UK comedy scene playing the title role in the online sitcom Chelsey OMG!, produced by comedy veterans Channel X. The series accrued more than an expected cult following, with over three million viewers.
Kelly-Anne's breakthrough role was as Kelly-Anne Manhattan, the lead female role in BBC's Dick and Dom's Funny Business, in which she played the funny sidekick to children's favorites Dick and Dom.
Lyons became known for her various outrageous characters in hidden camera shows such as MTV's Flash Prank, Channel 5's Secret Interview, ITV1's Fool Brittania, BBC1's Richard Hammond's Secret Service, and National Geographic's Ape Man.
Beginning May 2013, Lyons has played news anchor Felicity Bond in CBBC's new topical comedy news show, DNN. In July 2013, Kelly-Anne plays Tess in the BBC3 sitcom Badults.
Lyons is Celebrity Supporter for the Arthritis Care Charity. She has been in remission from her Juvenile Arthritis for ten years.
On St. Georges Day 2012, Lyons became a British Citizen, therefore making her a dual citizen of the USA and England.
