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At 17, Deborah moved to New York City to study acting and quickly expanded into writing and producing indie films. Her debut feature, A Gun For Jennifer (1997), screened at over 27 film festivals and became a cult hit in Europe. She then produced and starred in the indie film Molotov Samba. Shortly thereafter, with her eighteen-month-old son in a stroller and her baby daughter in a Bjorn, Deborah wrote, starred in, and directed In-Between, a supernatural 9/11 thriller.
She also wrote, starred in, and directed A Cry From Within, featuring Eric Roberts, Cathy Moriarty, and James McCaffrey, followed by Confidence Game, which starred Sean Young, James McCaffrey, and Robert Clohessy.
In recent years, Deborah has ventured into episodic content, writing, producing, and starring in the supernatural thriller pilot A Beautiful Distraction, starring Sean Young, Adrian Paul, and Vivica Fox. The full first season is scheduled for production in spring 2024. In fall 2023, the first season of Crazytown, a dark comedy about the strip club world, premiered globally on streaming platforms.
Most recently, Deborah celebrated the release of the Dogma95-style thriller Sapsiosexual, distributed by Breaking Glass Pictures in May 2023 and currently available on platforms including Amazon and Tubi.
Her Director's Cut of Sebastien (A Cry From Within), which includes 20 minutes of additional footage featuring Tom Pelphrey, premiered on TubiTV on December 1, 2021, and remains a top performer for distributor Breaking Glass Pictures.
In December 2023, Twiss and her team will be filming the thriller Broken, starring Michael Paré and several other notable actors.
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